
2 sessions
Smoother under-eye area with softer-looking fine lines.
Evolution Aesthetics Clinic

Polynucleotides for skin quality
Plinest is a fish-derived polynucleotide gel injected into the skin. Polynucleotides, or PN, are purified DNA fragments. Treatment aims to improve skin quality, including texture and elasticity. Changes develop gradually and vary between people.
At Evolution Clinic in Jumeira, we offer Plinest Gel for facial skin and Plinest Eye for the delicate eye area. Our doctor assesses the cause of your concern before choosing a product. Plinest does not relax facial muscles like Botox or provide the same correction as a structural filler.
service options
Two products, with a plan for the skin you want to treat. We explain which option fits your assessment.
key facts
We discuss what can change, what may remain and whether injections are suitable.

Assessment before treatment
We examine your skin, discuss your goals and review your health and previous treatments. For the eye area, we assess the skin, pigmentation, shadows and swelling separately.
We show you the selected product and explain likely benefits, limits, risks and the total price. If you proceed, your doctor places small injections in the agreed areas. We discuss numbing, but injections can still sting.
You receive written aftercare and a clear contact route for follow-up. Tell us about an event or travel so we can plan around possible visible marks.
Real results
These catalogue examples show individual results. The starting skin condition, treated area and treatment course differ. A photograph does not predict your result.
Individual results may vary.

Smoother under-eye area with softer-looking fine lines.

Brighter-looking skin with a rested, refreshed finish.

Smoother eye-area texture with softer-looking crow's-feet.

More even surface with less visible redness.
Questions
It may improve the appearance of some dark circles and the surrounding skin. Pigment, visible vessels, shadows and swelling can all contribute, so we first assess the cause. A recent Plinest Eye study reported improvement, but it had no untreated comparison group. Treatment cannot promise to remove every dark circle, correct substantial hollows or remove eye bags.
We agree a course after assessing your skin and goals. Published Plinest studies often use three sessions, separated by a few weeks. This is a study pattern, not a fixed prescription for you. We explain the number, spacing and review points for your product, then adjust the plan to your response.
Changes develop over the weeks after treatment. Early swelling is not the final result. Studies have followed improvements for several months, but they do not establish one duration for everyone. We review photographs and your experience before discussing maintenance. More treatment is not automatically better.
The quotation depends on whether we treat the face, eye area or both, the product amount and the agreed course. We state the complete price and explain consultation and follow-up terms before consent. A price for one service does not automatically include both products or every visit in a course.
“Salmon DNA” is a common search name for fish-derived injectable treatments. Plinest contains purified polynucleotides; its manufacturer describes a fish source, and Plinest research identifies trout. PN and PDRN are related terms used for different DNA-based materials. They are not a reason to treat all products, concentrations or evidence as interchangeable.
Small raised injection points, redness, swelling or bruises may remain visible. Recovery varies, especially around the eyes. Plan some space before an important event and follow your written aftercare. Contact us if symptoms increase, persist or worry you. Do not press or try to drain a bump yourself.
Treatment guides
Read our available guides for more detail about skin treatments and the questions to discuss at consultation.

Understand which dark-circle concerns Plinest Eye may help, what injections cannot correct, and why an eye-area assessment comes first.

A practical guide to Plinest recovery, gradual results, review appointments and warning signs, without a fixed promise for sessions or duration.
Our doctors assess your needs and provide treatment within their approved scope and clinical privileges.

Specialist Dermatologist
Medical Director of Evolution Clinic, Specialist Dermatologist from Russia, M.D., Official Trainer for Laser Technologies. DHA License 03624607-001
Meet Yulia
General Practitioner
General Practitioner at Evolution Aesthetics Clinic in Dubai. DHA License 39929792-001.
Meet VeraTell us which area concerns you and what you hope to change. We can arrange a consultation and explain the available appointment options.
Plinest Gel is an option when the goal is better skin quality rather than a change in facial shape. We assess texture, fine lines and elasticity alongside your current skin care and previous treatments. The gel holds water within the treated tissue. Clinical studies suggest improvements in skin appearance, but the size and duration of the benefit vary.
Small Plinest studies have reported changes in elasticity and appearance over several months. Evidence remains limited: studies differ in their methods, and some have no comparison group. This does not justify a promise to rebuild all collagen, reverse ageing or give a lifting result.
Plinest Eye is a distinct formulation for skin around the eyes. It is not simply the same face treatment with a new name. We discuss whether your concern is thin-looking skin, fine texture, pigment, a shadow or swelling before recommending it.
Dark circles can have several causes at once. Better skin quality may soften their appearance without removing the underlying cause. A course of Plinest Eye cannot be relied on to correct prominent eye bags or substantial volume loss. We explain when a different assessment or treatment is more suitable.
These treatments address different problems. Botox reduces selected muscle movement. Structural fillers replace volume in selected areas. Plinest treatment focuses on skin quality, although an injected gel and early swelling can temporarily change fullness. We do not promise that it causes no volume change.
The most useful starting point is the change you want, not a product name. If expression lines are your main concern, our Botox treatment page explains that option. A combined plan requires its own assessment; one treatment does not make another necessary.
Bring a list of medicines and supplements, including blood thinners and pain medicines. They can affect bleeding and bruising. Do not stop prescribed medicine on your own. Tell us about previous fillers, skin treatments, cold sores, unusual scars and any past reaction to an injectable.
Tell us if you have an autoimmune condition, reduced immunity, cancer treatment or a condition that affects healing. These need medical review before an elective injection. Give us details of current or recent isotretinoin, rather than choosing a waiting period from a general online checklist.
Follow the written instructions for your exact product and treated area. For Plinest Gel, manufacturer guidance advises no makeup for 12 hours and avoiding prolonged sun or UV exposure, sauna and steam until the red marks have healed. We explain the plan for Plinest Eye at your appointment.
Keep the area clean and handle it gently. Ask us when to resume exercise, active skin-care products, facials or other cosmetic treatment. Your recovery and the next treatment matter more than copying another person’s timetable.
We explain when to return and what changes to watch for. Bring up persistent bumps, swelling, discomfort or an uneven appearance. Do not book extra injections to correct an early result without review. Your longer-term plan may include maintenance, a different approach or no further injections.
We do not use Plinest in people with a known allergy to its ingredients or fish-derived products, or inject through infected or inflamed skin. Plinest treatment is not recommended during pregnancy or breastfeeding, for people under 18, or for people with autoimmune disease. We discuss suitable alternatives or timing.
The injections can cause pain, bruising, swelling, redness and raised points. Around the eyes, even modest swelling may be noticeable. Infection and allergic reactions are possible. We explain material risks for the selected product and area before you consent.
Contact us promptly for symptoms that worsen or fail to settle. Painful, hot, swollen skin or feeling unwell can indicate infection and needs urgent medical assessment. Do not assume that every reaction is normal healing.
Get emergency medical help immediately for trouble breathing, swelling of the tongue or throat, or collapse. Do not wait for a routine clinic reply.
Evolution Aesthetics Clinic holds DHA Polyclinic License 6000514. Our doctors work within their licensed scope and clinical privileges. We buy authentic products through official, authorized suppliers and follow the required storage and handling instructions. Our treatment supplies meet applicable UAE regulatory requirements. We are happy to show you the paperwork.
We explain the product, expected benefit, risks, alternatives and total price before you consent. Written aftercare and a clear route for follow-up are part of your care.
Related reading
Explore related treatment options and the sources behind our information.
Personalised consultation
A licensed clinician will review your goals, medical history, treatment options, expected results, and individual risks before you decide.
Umm Al Sheif Road 49, Dubai
Open every day · 9:00 to 21:00